Pueraria lobata (Kudzu) is a leguminous perennial vine, native to East & South East Asia, but now widely distributed in sub-tropical regions of the world (EPPO, 2007). The tuberous roots of P. mirifica primarily contain the active component miroestrol and its derivative, deoxymiroestrol.Chansakaow 2000 The tuberous roots of P. mirifica also contain daidzin, daidzein, genistin, genistein, puerarinIngham 1986 mirificoumestan, kwakhurinIngham 1986, Tahara 1987 coumestrolIngham 1988 mirificin, and 2 steroids, estrone and estriol.Sookvanichsilp 2008, Ingham 1986, Ingham 1989, Chansakaow 2000 The manufacture and synthesis of miroestrol is documented.Corey 1993, Ishikawa 2006 Deoxymiroestrol was isolated and identified as the most active phytoestrogen of the plant.Cherdshewasart 2004, Sookvanichsilp 2008, Ishikawa 2001. Kudzu flowers can be used in the form of tea. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Pueraria Mirifica is also called Kwao Krua or more specifically White Kwao Krua. Ohwi, has been widely used in China and, to a lesser extent, in Japan, Korea, and the U … If taken orally, the generally recommended dosage is a total of 500 mg/day. Get our free 5-day course on the essentials of supplementation. https://examine.com/supplements/pueraria-lobata/, © 2011-2020 Examine.com Inc | Privacy | Terms of Service | Disclaimer | About Us | Contact Examine.com, Small boost in attention in menopausal women (independent of reductions in symptoms of menopause); needs to be reinvestigated. She is known worldwide as The Cosmetics Cop and creator of Paula’s Choice Skincare. Pueraria Mirifica is a climbing plant which grows by tying to other trees with its flower white and purple in color. Each member of our research team is required to have no conflicts of interest, including with supplement While getting older is unavoidable, there are things you can do to reduce … All factual claims are followed by specifically-applicable references. About the Experts. Recommended dosage, active amounts, other details In regards to Pueraria Mirifica (White Kwao Krua), a dose of 20-50mg of the herb is taken daily once in the morning. The lone study on Kudzu root used a product containing 100mg of isoflavone equivalents, which appeared to be slightly effective for promoting cognition in postmenopausal women. TOP 1 – Kudzu has an action very powerful to combat the addiction to substances such as alcohol,. Suvatabhandu.Common Name(s): Kwao Keur, Kwao Krua, Kwao Kruea, White Kwao Krua. Scientific research does not always agree. The plant species P. mirifica (pueraria) belongs to the Fabaceae, or bean, subfamily, and its tuberous roots contain several phytoestrogens.Manonai 2007 P. mirifica is a woody vine commonly found in forests throughout ThailandMalaivijitnond 2006 with 28 cultivars presently documented. Commercial manufacturers suggest 250 mg (root or tuber) by mouth every morning and evening. mirifica had an estrogenic action in aged menopausal monkeys by changing the sexual skin area around the perineum to the base of the tail to a reddish pigmentation.Trisomboon 2006 FSH may be a candidate marker for the study of P. mirifica's estrogenic effects in female monkeys if changes in urinary hormones are used as an indicator.Trisomboon2007, Trisomboon 2007, In a 24-week randomized, double-blind, placebo-controlled trial of 51 postmenopausal women, oral P. mirifica exhibited estrogenicity on vaginal tissue, alleviated vaginal dryness symptoms and dyspareunia, improved signs of vaginal atrophy, and restored atrophic vaginal epithelium.Manonai 2007 In another clinical trial of 51 postmenopausal women 46 to 60 years of age, P. mirifica tuberous root had an estrogen-like effect on bone turnover rate at a dose of 20, 30, and 50 mg/day for a 24-week period.Manonai 2008 Phase 1 to 3 trials in Thailand compared the estrogenic effect of P. mirifica to conjugated equine estrogen in relieving climacteric symptoms in perimenopausal women.Lamlertkittikul 2004, Chandeying 2007, A small (n=52) clinical study evaluated oral P. mirifica at 25 and 50 mg over 6 months in relieving menopausal symptoms, and reported efficacy for both doses. This appears to be significantly bioactive, and it would be advisable to not exceed this dosage. Histopathological analysis of the mammary tumor tissues revealed lower ER-alpha, ER-beta, and ER-alpha/ER-beta profile.Cherdshewasart 2007, Cognitive improvements were reported in ovariectomized rats administered P. mirifica extract and pure puerarin, with the researchers suggesting potential applications in cognitive decline due to ageing.Anukulthanakorn 2016, The active ingredients from the root of P. mirifica had lethal properties during various growth cycles against the yellow fever mosquito (Aedes aegypti) and other mosquito species with disease-spreading abilities.Lapcharoen 2005. mirifica also had an estrogenic effect on a human HepG2 hepatoma cell line that contained an estrogen receptor and a luciferase reporter gene; this evidence indicates that metabolic activation of P. mirifica promotes estrogenic activity.Lee 2002 Another study also documents that estrogenic activity may result from metabolic activation of liver enzymes.Cherdshewasart 2008, The proposed mechanism of action involves strong competitive binding of the plant's phytoestrogens to ER-alpha and/or synthesis suppressor of ER-alpha.Cherdshewasart 2007, Pretreatment of rats with P. mirifica (1,000 mg/kg body weight per day tuberous root powder) resulted in decreased virulence of rat mammary tumor development from 7,12-dimethylbenz(a)anthracene (7,12-DMBA). 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